p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.

@article{Mesplde2012p53DA,
  title={p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes.},
  author={Thibault Mespl{\`e}de and David Gagnon and Fanny Bergeron-Labrecque and Ibrahim Azar and H{\'e}l{\`e}ne S{\'e}n{\'e}chal and François Coutl{\'e}e and Jacques Archambault},
  journal={Journal of virology},
  year={2012},
  volume={86 1},
  pages={94-107}
}
Human papillomaviruses (HPVs) are the etiological agents of cervical cancer and other human malignancies. HPVs are classified into high- and low-risk genotypes according to their association with cancer. Host cell transformation by high-risk HPVs relies in part on the ability of the viral E6 protein to induce the degradation of p53. We report the development of a cellular assay that accurately quantifies the p53 degradation activity of E6 in vivo, based on the fusion of p53 to Renilla… CONTINUE READING