p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase δ1

@article{Plaster2006p53DR,
  title={p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase δ1},
  author={Nikki Plaster and Carmen Sonntag and Christian E. Busse and Matthias Hammerschmidt},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={223-235}
}
Cell culture work has identified the tumor suppressor p53 as a component of the S-phase checkpoint control system, while in vivo studies of this role of p53 in whole-vertebrate systems were limited. Here, we describe zebrafish mutants in the DNA polymerase delta catalytic subunit 1, based on the positional cloning of the flathead (fla) gene. fla mutants display specific defects in late proliferative zones, such as eyes, brain and cartilaginous elements of the visceral head skeleton, where cells… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Eukaryotic DNA polymerases.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Checking on DNA damage in S phase

The C-terminal zinc finger of the catalytic subunit of DNA polymerase d is responsible for direct interaction with the B-subunit

  • J Sanchez Garcia, LF Cuifo, SE Kearsey, SA MacNeill
  • Nucl. Acids Res
  • 2004

Apoptosis - the p53 network.

VIEW 2 EXCERPTS