p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.

@article{Baek2003p53DA,
  title={p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.},
  author={Kwan-Hyuck Baek and Hyun-Jin Shin and Jae-Kwang Yoo and Junkwon Cho and Yo-Han Choi and Young Chul Sung and Frank Mckeon and Chang-woo Lee},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 6},
  pages={
          850-61
        }
}
During the proliferation of T cells for successful immune responses against pathogens, the fine regulation of cell cycle is important to the maintenance of T cell homeostasis and the prevention of lymphoproliferative disorders. However, it remains to be elucidated how the cell cycle is controlled at the mitotic phase in proliferating T cells. Here, we show that during the proliferation of primary T cells, the disruption of the mitotic spindle leads to cell-cycle arrest at mitosis and that… CONTINUE READING

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