p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.

@article{Leonova2013p53CW,
  title={p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.},
  author={Katerina I. Leonova and Leonid Brodsky and Brittany C. Lipchick and Mahadeb Pal and Liliya R. Novototskaya and Alex A. Chenchik and Ganes C Sen and Elena A. Komarova and Andrei V. Gudkov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 1},
  pages={E89-98}
}
Large parts of mammalian genomes are transcriptionally inactive and enriched with various classes of interspersed and tandem repeats. Here we show that the tumor suppressor protein p53 cooperates with DNA methylation to maintain silencing of a large portion of the mouse genome. Massive transcription of major classes of short, interspersed nuclear elements (SINEs) B1 and B2, both strands of near-centromeric satellite DNAs consisting of tandem repeats, and multiple species of noncoding RNAs was… CONTINUE READING
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