p53 control of bone remodeling.

  title={p53 control of bone remodeling.},
  author={Huijuan Liu and Bichun Li},
  journal={Journal of cellular biochemistry},
  volume={111 3},
Tumor suppressor p53 is a transcription regulator that displays anti-proliferation activities once activated by stress, in particular genotoxic stress. Recent mouse genetic studies revealed a critical role for p53 in bone remodeling, supported by both loss-of-function and gain-of function studies. p53 deficiency concurrently enhances proliferation and accelerates differentiation in mesenchymal stem cells and osteoprogenitor cells, resulting in an increase in bone formation and bone mass/density… CONTINUE READING

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