p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis.

@article{Hussain2006p53BN,
  title={p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis.},
  author={S. Perwez Hussain and C. C. Harris},
  journal={Journal of Nippon Medical School = Nippon Ika Daigaku zasshi},
  year={2006},
  volume={73 2},
  pages={54-64}
}
p53 as a key molecular node in the stress response pathway, including inflammation. p53 is involved in several critical pathways including cell cycle arrest, apoptosis, DNA repair, and cellular senescence, which are essential for normal cellular homeostasis and maintaining genome integrity. The alteration of the TP53 gene or posttranslational modification in the p53 protein can alter its response to cellular stress. The molecular archaeology of the TP53 mutation spectrum generates hypotheses… CONTINUE READING
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