p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.

@article{Ori1998p53BA,
  title={p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.},
  author={Assaf Ori and Ayelet Zauberman and Gilad Doitsh and Nir Paran and Moshe Oren and Yosef Shaul},
  journal={The EMBO journal},
  year={1998},
  volume={17 2},
  pages={544-53}
}
The transcription program of the hepatitis B virus (HBV) genome is regulated by an enhancer element that binds multiple ubiquitous and liver-enriched transcription activators. HBV transcription and replication are repressed in the presence of p53. Here we describe a novel molecular mechanism that is responsible for this repression. The p53 protein binds to a defined region within the HBV enhancer in a sequence-specific manner, and this, surprisingly, results in p53-dependent transcriptional… CONTINUE READING
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