p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.


Cell cycle checkpoints are safeguards that ensure the initiation of downstream events only after completion of upstream processes. The tumor suppressors p53 and pRb prevent initiation of a second round of replication in response to spindle inhibitors, but it has yet to be proven that this is a mitotic checkpoint response. We show that asynchronous human… (More)


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