p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

Abstract

Cell cycle checkpoints are safeguards that ensure the initiation of downstream events only after completion of upstream processes. The tumor suppressors p53 and pRb prevent initiation of a second round of replication in response to spindle inhibitors, but it has yet to be proven that this is a mitotic checkpoint response. We show that asynchronous human… (More)

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