p53 and chemosensitivity in bladder cancer

  title={p53 and chemosensitivity in bladder cancer},
  author={Hiroyuki Nishiyama and Jun Watanabe and Osamu Ogawa},
  journal={International Journal of Clinical Oncology},
Urothelial carcinoma is the second most common genitourinary malignancy. Although the majority of patients present with superficial bladder tumors, there are several clinical problems, such as progression to invasive tumors, poor prognosis of invasive tumors, and chemosensitivity. Alterations in p53 represent one of the most common genetic events in patients with invasive urothelial carcinoma and are suggested to be linked to tumor progression, prognosis, and chemosensitivity. p53 possesses… CONTINUE READING


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Cancer - specifi c enhancement of cisplatininduced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase3 beta with p 53

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