p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study

@article{Tan2005p53AC,
  title={p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study},
  author={Puay-Hoon Tan and Thiyagarajan Jayabaskar and George Yip and Yen Yen Tan and Maryam Hazly Hilmy and Sathiyamoorthy Selvarajan and B. -H. Bay},
  journal={Modern Pathology},
  year={2005},
  volume={18},
  pages={1527-1534}
}
Breast phyllodes tumors are fibroepithelial neoplasms whose clinical behavior is difficult to predict on histology. There is relatively scant data on the role of biological markers. In this study, we determined if p53 and CD117 (c-kit) protein expression was predictive of behavior in a series of 335 phyllodes tumors diagnosed at the Singapore General Hospital, using immunohistochemistry on tissue microarrays. Representative areas from 250 (75%) benign, 54 (16%) borderline and 31 (9%) malignant… CONTINUE READING
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