p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

@inproceedings{MarcetOrtega2017p53AT,
  title={p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes},
  author={Marina Marcet-Ortega and Sarai Pacheco and Ana Mart{\'i}nez-Marchal and Helena Castillo and Elsa Renee Flores and Maria Jasin and Scott Keeney and Ignasi Roig},
  booktitle={PLoS genetics},
  year={2017}
}
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). Here, we asked if p53 family members-targets of ATM and CHK2-participate in this arrest. We bred double-mutant mice combining a mutation of a… CONTINUE READING
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