p53 and Retinoblastoma protein (pRb): A complex network of interactions


p53 and the Retinoblastoma protein (pRb) are two oncosuppressive proteins whose loss of function is linked to the development of many cancers. Both of them play a central role in the regulation of both cell cycle and apoptosis. Different observations have led to a paradigm in which p53 and pRb can regulate each other, pRb playing an important role in the… (More)
DOI: 10.1007/s10495-006-5543-y


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@article{Godefroy2006p53AR, title={p53 and Retinoblastoma protein (pRb): A complex network of interactions}, author={Nelly Godefroy and Christophe Lemaire and Bernard Mignotte and J.-L. Vayssi{\`e}re}, journal={Apoptosis}, year={2006}, volume={11}, pages={659-661} }