p53 and Retinoblastoma protein (pRb): A complex network of interactions

Abstract

p53 and the Retinoblastoma protein (pRb) are two oncosuppressive proteins whose loss of function is linked to the development of many cancers. Both of them play a central role in the regulation of both cell cycle and apoptosis. Different observations have led to a paradigm in which p53 and pRb can regulate each other, pRb playing an important role in the… (More)
DOI: 10.1007/s10495-006-5543-y

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Cite this paper

@article{Godefroy2006p53AR, title={p53 and Retinoblastoma protein (pRb): A complex network of interactions}, author={Nelly Godefroy and Christophe Lemaire and Bernard Mignotte and J.-L. Vayssi{\`e}re}, journal={Apoptosis}, year={2006}, volume={11}, pages={659-661} }