p53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus.

@article{Fortunato1998p53AR,
  title={p53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus.},
  author={E. Fortunato and Deborah H. Spector},
  journal={Journal of virology},
  year={1998},
  volume={72 3},
  pages={2033-9}
}
Previously, we reported that human cytomegalovirus (HCMV) infection of fibroblasts markedly affects p53 and other regulatory proteins and inhibits transit through the cell cycle (F. M. Jault, J.-M. Jault, F. Ruchti, E. A. Fortunato, C. Clark, J. Corbeil, D. D. Richman, and D. H. Spector, J. Virol. 69:6697-6704, 1995). Although the p53 steady-state levels are elevated throughout the infection, evidence suggests that the ability of p53 to transactivate some of its downstream targets is… CONTINUE READING

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