p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction

@article{Moll2006p53AN,
  title={p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction},
  author={Ute M. Moll and Natalia D. Marchenko and X-k Zhang},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4725-4743}
}
The complex apoptotic functions of the p53 tumor suppressor are central to its antineoplastic activity in vivo. Conversely, p53 function is altered or attenuated in one way or another in the majority of human cancers. Besides its well-understood action as a transcriptional regulator of multiple apoptotic genes, p53 also exerts a direct pro-apoptotic role at the mitochondria by engaging in protein–protein interactions with anti- and pro-apoptotic Bcl2 family members, thereby executing the… CONTINUE READING
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