p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.

Abstract

Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have identified oligodendrocyte precursor cell (OPC) as the cell of origin for glioma following… (More)
DOI: 10.1002/glia.23297

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