p53 and K-ras mutations in lung cancers from former and never-smoking women.

@article{Vhkangas2001p53AK,
  title={p53 and K-ras mutations in lung cancers from former and never-smoking women.},
  author={Kirsi H. V{\"a}h{\"a}kangas and William P. Bennett and K Castr{\'e}n and J A Welsh and M A Khan and B Bl{\"o}meke and M C Alavanja and C C Harris},
  journal={Cancer research},
  year={2001},
  volume={61 11},
  pages={4350-6}
}
Somatic p53 mutations are common in lung cancer. Active cigarette smoking is positively correlated with the total frequency of p53 mutations and G:C to T:A transversions on the nontranscribed (DNA coding) strand. Mutational hotspots within the p53 gene, e.g., codon 157, have been identified for tobacco-related lung cancer, whereas these same mutations are found rarely in other cancers. Such data implicate specific p53 mutations as molecular markers of smoking. Because limited data exist… CONTINUE READING