p53 and ATM: cell cycle, cell death, and cancer.

@article{Morgan1997p53AA,
  title={p53 and ATM: cell cycle, cell death, and cancer.},
  author={Susan E. Morgan and Michael B. Kastan},
  journal={Advances in cancer research},
  year={1997},
  volume={71},
  pages={
          1-25
        }
}
The development of a normal cell into a tumor cell appears to depend in part on mutations in genes that normally control cell cycle and cell death, thereby resulting in inappropriate cellular survival and tumorigenesis. ATM ("mutated in ataxia-telangiectasia") and p53 are two gene products that are believed to play a major role in maintaining the integrity of the genome such that alterations in these gene products may contribute to increased incidence of genomic changes such as deletions… CONTINUE READING

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