p53 alterations in uterine leiomyosarcomas versus leiomyomas.

  title={p53 alterations in uterine leiomyosarcomas versus leiomyomas.},
  author={Sven de Vos and Sharon P. Wilczynski and Michael Fleischhacker and Phillip H. Koeffler},
  journal={Gynecologic oncology},
  volume={54 2},
Leiomyoma is the most common benign smooth muscle tumor. Although rare in other organs, it is frequent in the uterus, occurring in nearly 40% of women over 50 years of age. These benign tumors rarely undergo malignant transformation. The incidence of leiomyosarcomas in uterine leiomyomas is estimated to be between 0.13 and 0.29%. Little is known of the genetic abnormalities leading to this neoplasia. Loss of p53 function has been implicated in the pathogenesis of many human tumors. We evaluated… CONTINUE READING