p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

@article{Wales1995p53AE,
  title={p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3},
  author={Michele Makos Wales and Margaret A. Biel and Wafik El Deiry and Barry D. Nelkin and Jean-Pierre Issa and Webster K Cavenee and Steven J. Kuerbitz and Stephen B. Baylin},
  journal={Nature Genetics},
  year={1995},
  volume={1},
  pages={570-577}
}
For several human tumour types, allelic toss data suggest that one or more tumour suppressor genes reside telomeric to the p53 gene at chromosome 17p13.1. In the present study we have used a new strategy, involving molecular analysis of a DNA site hypermethylated in tumour DNA, to identify a candidate gene in this region (17p13.3). Our approach has led to… CONTINUE READING