p53 abnormalities in splenic lymphoma with villous lymphocytes.

@article{GRUSZKAWESTWOOD2001p53AI,
  title={p53 abnormalities in splenic lymphoma with villous lymphocytes.},
  author={ALICJA M. GRUSZKA-WESTWOOD and Rifat A. Hamoudi and Estella Matutes and Esperanza Tuset and Daniel Catovsky},
  journal={Blood},
  year={2001},
  volume={97 11},
  pages={3552-8}
}
The incidence and role of p53 abnormalities have not been reported in splenic lymphoma with villous lymphocytes (SLVL), the leukemic counterpart of splenic marginal zone lymphoma. Because p53 abnormalities correlate with progressive and refractory disease in cancer and isochromosome 17q has been described in SLVL, a low-grade lymphoma that behaves aggressively in a minority of patients, this study investigated p53 changes by molecular and immunophenotypic methods in samples from 59 patients… CONTINUE READING

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