p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

@article{Budanov2008p53TG,
  title={p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling},
  author={Andrei V. Budanov and Michael Karin},
  journal={Cell},
  year={2008},
  volume={134},
  pages={451-460}
}
The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose activity is inhibited by the TSC1:TSC2 complex. Although genotoxic stress has been suggested to inhibit mTOR via p53-mediated activation of mTOR inhibitors, the precise mechanism of this link was unknown. We now demonstrate that the products of two p53 target genes, Sestrin1 and… CONTINUE READING
Highly Influential
This paper has highly influenced 49 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 427 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

The regulation of AMPK {beta}1, TSC2, and PTEN expression by p53: Stress, cell and tissue dpecificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

  • Z. Feng, W. Hu, +4 authors A. J. Levine
  • Cancer Res
  • 2007
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…