p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.

@article{Dinca2008p53SI,
  title={p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.},
  author={Eduard B. Dinca and Kan V. Lu and Jann N. Sarkaria and Russell O. Pieper and Michael D. Prados and Daphne Adele Haas-Kogan and Scott R. Vandenberg and Mitchel S. Berger and C. David James},
  journal={Cancer research},
  year={2008},
  volume={68 24},
  pages={10034-9}
}
In this study, we investigated the precursor and active forms of a p53 small-molecule inhibitor for their effects on temozolomide (TMZ) antitumor activity against glioblastoma (GBM), using both in vitro and in vivo experimental approaches. Results from in vitro cell viability analysis showed that the cytotoxic activity of TMZ was substantially increased when p53 wild-type (p53(wt)) GBMs were cotreated with the active form of p53 inhibitor, and this heightened cytotoxic response was accompanied… CONTINUE READING

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