p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: is it an early or late event?

@article{Levi1996p53PO,
  title={p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: is it an early or late event?},
  author={Eldad Levi and Steven J. Stryker and M. Sathyanarayana Rao},
  journal={The American journal of gastroenterology},
  year={1996},
  volume={91 1},
  pages={
          11-4
        }
}
OBJECTIVES Tumor development is a multistep process associated with multiple genetic alterations. Familial adenomatous polyposis (FAP) is a classical paradigm to study genetic alterations in the development of colorectal neoplasms. In this study, we investigated the timing of p53 overexpression by immunohistochemistry in colorectal carcinogenesis in FAP patients and in sporadic adenomas and adenocarcinomas. METHODS We examined 40 microadenomas, 114 tubular adenomas, and three adenocarcinomas… CONTINUE READING

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