p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior.

@article{Shanmugam2008p53NA,
  title={p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior.},
  author={Chandrakumar Shanmugam and Venkat Rao Katkoori and Nirag C. Jhala and William E. Grizzle and Gene P. Siegal and Upender Manne},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2008},
  volume={56 3},
  pages={305-12}
}
For subsets of colorectal adenocarcinoma (CRC) patients, nuclear accumulation of p53 (p53(nac)) and Bcl-2 expression are prognostic indicators. To understand their role in the progression of CRC we evaluated 90 CRCs and their contiguous adenomatous components (CAdCs) for immunohistochemical expression of these markers. In general, p53(nac) and Bcl-2 expression was significantly increased when comparing normal colonic epithelia to CAdCs and CRCs. Thirteen (14%) CAdCs that demonstrated p53(nac… CONTINUE READING