p53-Mdm2 inhibitors: patent review (2009 - 2010).

  title={p53-Mdm2 inhibitors: patent review (2009 - 2010).},
  author={Ahmed Kamal and Ameruddin Azhar Mohammed and Thokhir Basha Shaik},
  journal={Expert opinion on therapeutic patents},
  volume={22 2},
INTRODUCTION p53 plays a central role in protecting the integrity of the genome. Its activity is ubiquitously lost in cancers, either by inactivation of its protein (p53 pathway) or by mutation in the p53 gene, thereby indicating its importance in understanding cancer and as a therapeutic target. Activated p53 is known to induce cell cycle arrest thereby leading to apoptosis and has been the subject of intensive research in the area of medicinal chemistry. Efforts are in progress to synthesize… CONTINUE READING

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