p53 Family and Cellular Stress Responses in Cancer

  title={p53 Family and Cellular Stress Responses in Cancer},
  author={Johanna Pflaum and Sophie Schlosser and Martina Mueller},
  booktitle={Front. Oncol.},
p53 is an important tumor suppressor gene, which is stimulated by cellular stress like ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to cell-cycle arrest and promotes DNA repair or induces apoptosis via several pathways. p63 and p73 are structural homologs of p53 that can act similarly to the protein and also hold functions distinct from p53. Today more than 40 different isoforms of the p53 family members are known. They result from transcription via… CONTINUE READING
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