p53 Expression and Environmental Tobacco Smoke Exposure in Feline Oral Squamous Cell Carcinoma

@article{Snyder2004p53EA,
  title={p53 Expression and Environmental Tobacco Smoke Exposure in Feline Oral Squamous Cell Carcinoma},
  author={Laura A Snyder and Elizabeth R. Bertone and Richard M Jakowski and Mark Dooner and J Jennings-Ritchie and Antony S Moore},
  journal={Veterinary Pathology},
  year={2004},
  volume={41},
  pages={209 - 214}
}
The purpose of this study was to determine the prevalence of p53 overexpression in feline oral squamous cell carcinomas (SCC) and to determine, if any, the association between p53 overexpression and lifestyle factors and environmental exposures, including exposure to environmental tobacco smoke (ETS). Questionnaires concerning exposure to ETS and other environmental factors were sent to owners of cats presenting to the Harrington Oncology Program with a diagnosis of oral SCC between 1991 and… 
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References

SHOWING 1-10 OF 17 REFERENCES
Environmental and lifestyle risk factors for oral squamous cell carcinoma in domestic cats.
TLDR
Results of this study suggest that flea control products, diet, and perhaps environmental tobacco smoke might be associated with risk of oral SCC and indicate that further investigation into these relationships is warranted.
p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer.
TLDR
A significant 3-4-fold increased risk of p53 mutation is indicated in smoking lung cancer cases, and it suggests that mechanisms of lung carcinogenesis in ETS-exposed never-smokers include mutations in the p53 gene, similar to that seen in smokers.
A general review of the p53 gene and oral squamous cell carcinoma.
  • A. Jones
  • Medicine
    Annals of the Royal Australasian College of Dental Surgeons
  • 1998
TLDR
Molecular analysis has now detected an accumulation of genetic lesions in oral cancer, but the earliest molecular changes in the oral epithelium in the progression to malignancy in at-risk patients has not yet been determined.
Immunohistochemical analysis of 4-aminobiphenyl-DNA adducts in oral mucosal cells of smokers and nonsmokers.
TLDR
This study examined the dose-response relationship for 4-Aminobiphenyl-DNA adducts in oral cells of smokers and non smokers to suggest individual differences relevance in metabolizing carcinogens and/or repairing DNA damage.
Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers.
TLDR
It is demonstrated that the immunohistochemical method has sufficient sensitivity for detection of 4-ABP-DNA adducts in human bladder samples and there was a significant correlation between p53 overexpression and recurrence of disease.
Immunohistochemical detection of P53 overexpression in paraffin wax-embedded squamous cell carcinomas of cattle, horses, cats and dogs.
TLDR
The results support the view that, as in man, p53 overexpression plays an important role in the development of most SCCs of the animal species studied, and p53 antigen could be detected immunohistochemically in formalin-fixed and paraffin wax-embedded tissues of S CCs of domestic animals.
Immunohistochemical expression of p53 in animal tumors: a methodological study using four anti-human p53 antibodies.
TLDR
Immodetection of p53 protein is thus possible in all domestic species tested, especially with CM-1 and PAb-240 antibodies, and p53 alterations seem to occur early in carcinogenesis of feline SCC as in comparable human lesions.
p53 protein expression in conjunctival squamous cell carcinomas of domestic animals.
TLDR
Results demonstrate a frequent p53 overexpression in conjunctival squamous cell carcinoma that could be related to UV-induced mutations of the p53 tumor suppressor gene.
Spontaneous squamous cell carcinomas of the oral region in domestic animals: a review and consideration of their relevance to human research.
TLDR
Spontaneous squamous cell carcinomas of the oral region in domestic animals have the potential of providing additional information about the pathology of oral cancer and may be useful in therapeutic research and the use in research of such tumors in dogs and cats.
Immunoperoxidase quantitation of 4-aminobiphenyl- and polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral and urothelial cells of smokers and nonsmokers.
  • T. Hsu, Y. Zhang, R. Santella
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1997
TLDR
A similar 2-3-fold range in relative staining was found in smokers and nonsmokers for both 4-ABP- and PAH-DNA, suggesting the importance of individual differences in capacity to metabolize the carcinogens and/or repair damaged DNA.
...
1
2
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