p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes


THE tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents1,2. As p53 is a transcriptional activator3 that mediates gene induction after DNA damage4, it has been proposed to be a genetic switch that activates apoptosis-mediator genes5. Here we evaluate the role of p53 in DNA-damage-induced apoptosis by… (More)
DOI: 10.1038/370220a0


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