p53-Dependent Cell Death Signaling in Neurons

@article{Morrison2003p53DependentCD,
  title={p53-Dependent Cell Death Signaling in Neurons},
  author={Richard J S Morrison and Yoshito Kinoshita and Mark D. Johnson and Weiqun Guo and Gwenn A. Garden},
  journal={Neurochemical Research},
  year={2003},
  volume={28},
  pages={15-27}
}
The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and in brain tissue samples derived from animal models and patients with chronic neurodegenerative diseases. p53 deficiency or p53 inhibition protects neurons from a wide variety of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
68 Extracted Citations
144 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 68 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 144 references

Similar Papers

Loading similar papers…