p53-Dependent Cell Death Signaling in Neurons

  title={p53-Dependent Cell Death Signaling in Neurons},
  author={Richard J S Morrison and Yoshito Kinoshita and Mark D. Johnson and Weiqun Guo and Gwenn A. Garden},
  journal={Neurochemical Research},
The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and in brain tissue samples derived from animal models and patients with chronic neurodegenerative diseases. p53 deficiency or p53 inhibition protects neurons from a wide variety of… CONTINUE READING

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