p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury.

@article{Liu2009p53AL,
  title={p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury.},
  author={Gang Liu and Young-Jun Park and Yuko Tsuruta and Emmanuel F. Lorne and Edward Abraham},
  journal={Journal of immunology},
  year={2009},
  volume={182 8},
  pages={5063-71}
}
The transcriptional factor p53 has primarily been characterized for its central role in the regulation of oncogenesis. A reciprocal relationship between the activities of p53 and NF-kappaB has been demonstrated in cancer cells, but there is little information concerning interactions between p53 and NF-kappaB in inflammatory processes. In this study, we found that neutrophils and macrophages lacking p53, i.e., p53(-/-), have elevated responses to LPS stimulation compared with p53(+/+) cells… CONTINUE READING

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