p53: traffic cop at the crossroads of DNA repair and recombination


p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53… (More)
DOI: 10.1038/nrm1546


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