p53: The barrier to cancer stem cell formation

@article{AloniGrinstein2014p53TB,
  title={p53: The barrier to cancer stem cell formation},
  author={Ronit Aloni-Grinstein and Yoav Shetzer and Tom Kaufman and Varda Rotter},
  journal={FEBS Letters},
  year={2014},
  volume={588}
}
The role of p53 as the “guardian of the genome” in differentiated somatic cells, triggering various biological processes, is well established. Recent studies in the stem cell field have highlighted a profound role of p53 in stem cell biology as well. These studies, combined with basic data obtained 20 years ago, provide insight into how p53 governs the quantity and quality of various stem cells, ensuring a sufficient repertoire of normal stem cells to enable proper development, tissue… Expand
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