p53/58 Binds COPI and Is Required for Selective Transport through the Early Secretory Pathway

@article{Tisdale1997p5358BC,
  title={p53/58 Binds COPI and Is Required for Selective Transport through the Early Secretory Pathway},
  author={Ellen J. Tisdale and Helen Plutner and Jeanne L. Matteson and William Edward Balch},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={581 - 593}
}
p53/58 is a transmembrane protein that continuously recycles between the ER and pre-Golgi intermediates composed of vesicular-tubular clusters (VTCs) found in the cell periphery and at the cis face of the Golgi complex. We have generated an antibody that uniquely recognizes the p53/58 cytoplasmic tail. Here we present evidence that this antibody arrests the anterograde transport of vesicular stomatitis virus glycoprotein and leads to the accumulation of p58 in pre-Golgi intermediates… CONTINUE READING