p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma

@article{Alomari2014p40IA,
  title={p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma},
  author={Ahmed K. Alomari and Earl J. Glusac and Jennifer M. McNiff},
  journal={Journal of Cutaneous Pathology},
  year={2014},
  volume={41}
}
Poorly differentiated squamous cell carcinoma (SCC) of the skin may pose a diagnostic challenge for pathologists. p40 is a recently introduced antibody that recognizes specific p63 protein isoforms and has shown superior results labeling non‐cutaneous SCC. We hypothesize that p40 may improve diagnostic accuracy of poorly differentiated SCC. 
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References

SHOWING 1-10 OF 35 REFERENCES
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma
TLDR
Cutaneous spindle cell squamous cell carcinoma is a rare variant of SCC and p63 is a member of the p53 gene family that can be identified in epithelial malignancies.
The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma
TLDR
An expanded immunohistochemical evaluation of ultrastructurally documented SSCC is performed to assess its utility in diagnosing this entity.
The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas
TLDR
This work studies the utility of p63, CK 5/6, CK 7, and 20 expression in PCAN vs. MC to distinguish primary cutaneous adnexal neoplasms (PCANs) from metastatic carcinomas (MCs).
p40 Is More Specific Than p63 for the Distinction of Atypical Fibroxanthoma From Other Cutaneous Spindle Cell Malignancies
TLDR
It is shown that p40 and p63 exhibit comparable sensitivity, but p40 exhibits superior specificity in the distinction of AFX from SpSCC.
Keratin immunoreactivity in melanoma of soft parts (clear cell sarcoma)
TLDR
Seven of 24 soft tissue melanomas were shown to express keratins using antibodies CAM 5.2, LP34 and MNF116, and no clinical or histological differences were seen when compared with the 17 keratin negative cases.
Squamous cell carcinomas with single cell infiltration: a potential diagnostic pitfall and the utility of MNF116 and p63
TLDR
Four examples of SCC composed primarily of single, atypical cells that were cytokeratin (CK) MNF116‐positive and p63‐positive were encountered, and CK MNF 116 and/or p63 were diagnostically helpful in recognizing it.
p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma
Immunohistochemistry has recently emerged as a powerful ancillary tool for differentiating lung adenocarcinoma and squamous cell carcinoma—a distinction with important therapeutic implications.
Use of p40 and p63 Immunohistochemistry and Human Papillomavirus Testing as Ancillary Tools for the Recognition of Head and Neck Sarcomatoid Carcinoma and Its Distinction From Benign and Malignant Mesenchymal Processes
TLDR
P40 staining does not improve the sensitivity for diagnosing SC, but it does diminish the risk of misdiagnosing a sarcoma or reactive stroma as SC.
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract
TLDR
P40 is a more squamous-specific isoform of p63, and it may be more useful in distinguishing poorly differentiated SCC from its mimickers in the sinonasal tract, and therefore it should be utilized as part of an immunohistochemical panel.
Diagnostic utility of P63 and CD10 in distinguishing cutaneous spindle cell/sarcomatoid squamous cell carcinomas and atypical fibroxanthomas.
TLDR
Overall, the most effective combination to distinguish AFX from SCSCC was p63 and cytokeratin AE-1/3 and the usefulness of CD10 in this differential diagnosis is limited.
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