p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63.

Abstract

At present, p63, TTF-1, and Napsin-A are the main immunochemical markers used to distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC). However, studies using antibodies against p63 have demonstrated false-positive results with positivity in some ADC. In contrast, the expression of one of the p63 isoforms (ΔNp63), detected by the antibody p40, is highly specific for SCC. Since most cases of lung cancer are diagnosed in small specimens (cytology/biopsies) and saving material for molecular analysis is mandatory, we recommended the use of p40 (in adjunct with TTF-1 and/or Napsin-A) as the best approach to discriminate SCC and lung ADC. In this paper, we review the physiological and pathological role of p63 isoforms as well as their use as diagnostic markers in lung SCC.

DOI: 10.1159/000345245

3 Figures and Tables

0102030201520162017
Citations per Year

Citation Velocity: 7

Averaging 7 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Nobre2013p40AP, title={p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63.}, author={Ana Rita Nobre and Andr{\'e} Albergaria and Fernando Schmitt}, journal={Acta cytologica}, year={2013}, volume={57 1}, pages={1-8} }