p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion

  title={p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion},
  author={Felicia Li-Sher Tan and Aikseng Ooi and Dachuan Huang and Jing Chii Wong and Chaonan Qian and Cora Chao and London Lucien Ooi and Yu-meng Tan and Alexander Y F Chung and Peng-Chung Cheow and Zhongfa Zhang and David Petillo and Ximing J. Yang and Bin Tean Teh},
  journal={International Journal of Cancer},
Cholangiocarcinoma (CC) and hepatocellularcarcinoma (HCC) are two main forms of liver malignancies, which exhibit differences in drug response and prognosis. Immunohistotochemical staining for cytokeratin markers has been used to some success in the differential diagnosis of CC from HCC. However, there remains a need for additional markers for increased sensitivity and specificity of diagnosis. In this study, we have identified a p38 MAP kinase, p38δ (also known as MAPK13 or SAPK4) as a protein… 

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