p38b Mitogen-Activated Protein Kinase Signaling Mediates Exenatide-Stimulated Microglial b-Endorphin Expression

Abstract

Recent discoveries established that activation of glucagon-like peptide-1 receptors (GLP-1Rs) mediates neuroprotection and antinociception through microglial b-endorphin expression. This study aimed to explore the underlying signaling mechanisms of microglial b-endorphin. GLP-1Rs and b-endorphin were coexpressed in primary cultures of microglia. Treatment… (More)

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