p38MAPK inhibition prevents disease in pemphigus vulgaris mice.

  title={p38MAPK inhibition prevents disease in pemphigus vulgaris mice.},
  author={Paula Berkowitz and Peiqi Hu and Simon Warren and Zhi Liu and Luis A Diaz and David S. Rubenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 34},
Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease characterized by detachment of keratinocytes (acantholysis). It has been proposed that PV IgG might trigger signaling and that this process may lead to acantholysis. Indeed, we recently identified a rapid and dose-dependent phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and heat shock protein (HSP) 27 after binding of PV antibodies to cultured keratinocytes. In human keratinocyte cultures… CONTINUE READING
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