p38 mitogen-activated protein kinase mediates hyperosmolarity-induced vasoconstriction through myosin light chain phosphorylation and actin polymerization in rat aorta.

@article{Sasahara2013p38MP,
  title={p38 mitogen-activated protein kinase mediates hyperosmolarity-induced vasoconstriction through myosin light chain phosphorylation and actin polymerization in rat aorta.},
  author={Tomoya Sasahara and Katsutoshi Yayama and Hiroshi Okamoto},
  journal={Biological & pharmaceutical bulletin},
  year={2013},
  volume={36 11},
  pages={1849-56}
}
Hyperosmotic stress induces the contractile response of vascular smooth muscle cells (VSMCs). Previous studies have demonstrated that cytoskeleton reorganization and Rho/Rho-kinase-mediated inactivation of myosin light chain phosphatase (MLCP) play an important role in hyperosmotic vasoconstriction, but the precise mechanism is unknown. This study aimed to… CONTINUE READING