p38 mitogen-activated protein kinase downregulates endothelial progenitor cells.

@article{Seeger2005p38MP,
  title={p38 mitogen-activated protein kinase downregulates endothelial progenitor cells.},
  author={Florian Hartmut Seeger and Judith Haendeler and Dirk Walter and Ulrich Rochwalsky and Johannes Reinhold and Carmen Urbich and Lothar R{\"o}ssig and Anne Corbaz and Yolande Chvatchko and Andreas Michael Zeiher and Stefanie Dimmeler},
  journal={Circulation},
  year={2005},
  volume={111 9},
  pages={1184-91}
}
BACKGROUND Transplantation of endothelial progenitor cells (EPCs) improves neovascularization after ischemia, but patients with coronary artery disease (CAD) or diabetes mellitus show a reduced number of EPCs and impaired functional activity. Therefore, we investigated the effects of risk factors, such as glucose and TNF-alpha, on the number of EPCs in vitro to elucidate the underlying mechanisms. METHODS AND RESULTS EPCs of patients or healthy subjects were isolated from peripheral blood… CONTINUE READING