p38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,488H-induced conditioned place aversion

@article{Zan2016p38MP,
  title={p38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,488H-induced conditioned place aversion},
  author={Guocai Zan and Qiao Wang and Yu - Hsiang Juan Yon - CHeong Wong Li - Jen Wang CHen Wang and Jindong Chen and Xi Wu and C Yang and J-R Chai and Mei Li and Y Liu and X-W Hu and X-H Shu and Jing-Gen Liu},
  journal={Neuroscience},
  year={2016},
  volume={320},
  pages={122-128}
}
κ opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible involvement of p38 MAPK in the aversive effects induced by κ opioid receptor activation. We found that the κ opioid receptor agonist trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl… CONTINUE READING

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