p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.

  title={p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.},
  author={Mark R Frey and Rebecca S Dise and Karen L Edelblum and David Brent Polk},
  journal={The EMBO journal},
  volume={25 24},
Internalization and proteolytic degradation of epidermal growth factor (EGF) receptor (R) following ligand binding is an important mechanism for regulating EGF-stimulated signals. Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not internalization. In the absence of p38 activity, EGF fails to stimulate the ubiquitin ligase Cbl or ubiquitinylation of EGFR, and internalized… CONTINUE READING

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