p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells.

@article{SheikhHamad1998p38KA,
  title={p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells.},
  author={David Sheikh-Hamad and John F di Mari and Wadi N. Suki and Robert L. Safirstein and Bruns A. Watts and Dean Rouse},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={1832-7}
}
In renal cells, hypertonicity induces genes for heat shock proteins (HSP70, alpha B-crystallin), as well as enzymes and transporters directly involved in the metabolism and transport of protective organic osmolytes. While heat shock proteins are induced by many stresses including osmotic stress, the induction of the osmolytes genes appears to be specific to osmotic stress. These two adaptive mechanisms allow kidney cells to survive and function in the hypertonic environment that exists on… CONTINUE READING
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