p38-dependent enhancement of cytokine-induced nitric-oxide synthase gene expression by heat shock protein 70.

@article{Bellmann2000p38dependentEO,
  title={p38-dependent enhancement of cytokine-induced nitric-oxide synthase gene expression by heat shock protein 70.},
  author={Kerstin Bellmann and Volker Burkart and J Bruckhoff and Hubert Kolb and Jacques Landry},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 24},
  pages={18172-9}
}
Heat shock protein (hsp) 70 protects cells against stress by means of its ability to chaperone denatured proteins and to modulate stress-activated signaling pathways. Because inflammatory processes are often accompanied by hsp expression and because stress and cytokines share several signaling pathways, we investigated the possibility that hsp70 might modulate the cellular response to cytokines. We found that stable cell clones overexpressing hsp70, or cells shortly after transfection with… CONTINUE READING

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