p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis.

@article{Dhingra2007p38AE,
  title={p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis.},
  author={Sanjiv Dhingra and Anita K. Sharma and Dinender Kumar Singla and Pawan K. Singal},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 6},
  pages={H3524-31}
}
It is known that TNF-alpha increases the production of ROS and decreases antioxidant enzymes, resulting in an increase in oxidative stress. IL-10 appears to modulate these effects. The present study investigated the role of p38 and ERK1/2 MAPKs in mediating the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis in… CONTINUE READING