p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages.

@article{Li2003p38MP,
  title={p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages.},
  author={Xiaotong Li and Nobuyuki Udagawa and Masamichi Takami and Nobuaki Sato and Yasuhiro Kobayashi and Naoyuki Takahashi},
  journal={Endocrinology},
  year={2003},
  volume={144 11},
  pages={
          4999-5005
        }
}
We previously reported that p38 MAPK signaling is required for osteoclast differentiation but not osteoclast function. Here we further investigated the role of p38 MAPK in the function and differentiation of mouse bone marrow macrophages (BMM phi), common precursors of osteoclasts and dendritic cells. Lipopolysaccharide (LPS) activated the p38 MAPK signaling pathway in BMM phi by sequential phosphorylation of MAPK kinase 3/6, p38 MAPK, and activating transcription factor-2. Treatment of BMM phi… CONTINUE READING
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