p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY.

@article{Touyz2001p38MK,
  title={p38 Map kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY.},
  author={Rhian M Touyz and G He and Mohammed El Mabrouk and Ernesto L Schiffrin},
  journal={Hypertension},
  year={2001},
  volume={37 2 Pt 2},
  pages={574-80}
}
Vascular remodeling in hypertension is associated with cell growth and increased deposition of extracellular matrix components, particularly collagen. Mechanisms underlying these processes are unclear, but MAP kinases, particularly ERK1/2 and p38 MAP kinase, may be important. We studied the role of ERK1/2 and p38 MAP kinase in vascular smooth muscle cell (VSMC) collagen synthesis and growth mediated by angiotensin (Ang) II in spontaneously hypertensive rats (SHR). Cultured mesenteric VSMC from… CONTINUE READING
36 Extracted Citations
37 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 36 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 37 references

Differential activation of ERK1/2 and p38 MAP kinase by AT 1 receptors in vascular smooth muscle cells from WKY and SHR

  • RM Touyz, G He, M El Mabrouk, Q Diep, V Mardigyan, EL. Schiffrin
  • J Hypertens
  • 2001

Similar Papers

Loading similar papers…