p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19.

@article{Kimoto2004p38MM,
  title={p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19.},
  author={Kenichi Kimoto and Kazuo Nakatsuka and Noritaka Matsuo and Hidekatsu Yoshioka},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 7},
  pages={2431-7}
}
PURPOSE Transforming growth factor (TGF)-beta has been implicated as the key mediator of proliferative vitreoretinopathy, but the cellular mechanisms by which TGF-beta induces extracellular matrix protein (ECM) synthesis are not fully understood. The current study was conducted to examine whether the mitogen-activated protein kinase (MAPK) pathway is involved in TGF-beta 2-induced collagen expression in retinal pigment epithelial cells. METHODS Human retinal pigment epithelial cells ARPE-19… CONTINUE READING
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Cross-talk between ERK MAPkinase and Smad-signaling pathway enhances TGF- dependent responses in human mesangial cells

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