p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension.

@article{Ju2003p38MI,
  title={p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension.},
  author={Haisong Ju and David J. Behm and S N Nerurkar and Marianne E Eybye and Robin E. Haimbach and Alan R. Olzinski and Stephen A. Douglas and Robert Nicholas Willette},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 3},
  pages={
          932-8
        }
}
Numerous mediators, believed to play a role in endothelial dysfunction (e.g., neurohormones, cytokines, hypoxia, and stretch), have been shown to activate p38 mitogen-activated protein kinase (MAPK) in a variety of cell types. The purpose of the present study was to examine the regulation of p38 MAPK in endothelium and its role in endothelial dysfunction and salt sensitivity. In cultured human umbilical vein endothelial cells (HUVECs), tumor necrosis factor-alpha and lipopolysaccharide… CONTINUE READING

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