p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.

@article{BaezaRaja2004p38MN,
  title={p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.},
  author={Bernat Baeza-Raja and Pura Mu{\~n}oz-C{\'a}noves},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 4},
  pages={
          2013-26
        }
}
p38 MAPK and nuclear factor-kappaB (NF-kappaB) signaling pathways have been implicated in the control of skeletal myogenesis. However, although p38 is recognized as a potent activator of myoblast differentiation, the role of NF-kappaB remains controversial. Here, we show that p38 is activated only in differentiating myocytes, whereas NF-kappaB activity is present both in proliferation and differentiation stages. NF-kappaB activation was found to be dependent on p38 activity during… CONTINUE READING
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  • L. Vermeulen, G. De Wilde, P. Van Damme, W. Vanden Berghe, G. Haegeman
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